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doi:10.1002/jcp.25677 57

First, due to lacking experimental data, e.g

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Benowitz (1997) reported that from chewing tobacco, about 4.5 mg nicotine was systemically absorbed from an average dose of 7.9 g chewed for 30 min and an average of 3.6 mg nicotine was absorbed from 2.5 g moist snuff kept in the mouth for 30 min which are evidently much higher than absorption amounts from smoking cigarettes where an average of 1.0 mg nicotine was absorbed per cigarette

THC exposure during this vulnerable phase can lead to a range of short-term and long-term effects that may hinder a teens development and overall well-being